Significant reduction of humoral response to SARS-CoV-2 4 months after the diagnosis of COVID-19

Editor’s note A commentary on“Humoral immune response to SARS-CoV-2 in Iceland”.Humoral response to COVID-19 disease,including IgM and IgG antibodies against SARS-CoV-2 virus,is well documented.1,2 Neutralizing activities against SARS-CoV-2 virus have also been confirmed in patients who have recovered from COVID-19.2 These observations form the basis for the assumption that SARS-CoV-2 vaccines can be developed through stimulation of the host immune system to generate neutralizing antibodies to SARS-CoV-2 virus.