摘要
目的探讨SNP位点rs2070426多态性与食管癌患者生存期的关系。方法199例患者均来自郑州大学第一附属医院省部共建食管癌防治国家重点实验室食管癌患者临床信息数据库,均为河南省食管癌高发区行手术治疗的患者。采用(全基因组外显子测序WES)法检测组织样本,并以全因死亡为终点对患者进行随访,观察rs2070426位点多态性与患者预后的相关性。应用SPSS 26.0软件进行分析。结果基因型分析表明PCNT基因SNP位点rs2070426有3种基因型,其中GG型51例、GC型64例、CC型84例。不同基因型的食管癌患者在同一个时间段中的生存率不同,进行SPSS软件中的Kaplan-Meier分析比较,CC型患者的生存最好(P<0.001)。结论PCNT基因SNP位点rs2070426多态性与食管癌的生存状况密切相关,有一定的预后指导作用。
Objective To investigate the relationship between SNP rs2070426 polymorphism and survival of esophageal cancer patients.Methods 199 patients data were collected from our database.All patients were treated with surgery in the high incidence area of esophageal cancer in Henan Province.The tissue samples were detected by WES(whole exome sequencing)method,and patients were followed up with all-cause death as the end point,to observe the correlation between rs2070426 single nucleotide polymorphism and prognosis of esophageal cancer.SPSS 26.0 software was used for analysis.Results In them there were three genotypes of SNP rs2070426 in PCNT gene,including 51 cases of GG type,64 cases of GC type and 84 cases of CC type.The survival rates of esophageal cancer patients with different genotypes were different in the same period of time.Kaplan-meier analysis showed that CC type patients had the best survival rate(P<0.001).Conclusion This study showed that rs2070426 polymorphism of SNP in PCNT gene is closely related to the survival status of esophageal cancer,which plays a certain guiding role.
作者
乔佳欣
宋昕
徐瑞华
赵学科
魏梦霞
王苒
韩雪娜
陈亚杰
孙琳
马琳琳
谢叶真
白合林
罗宏
李爱丽
王立东
QIAO Jia-xin;SONG Xin;XU Rui-hua;ZHAO Xue-ke;WEI Meng-xia;WANG Ran;HAN Xue-na;CEHN Ya-jie;SUN Lin;MA Lin-lin;XIE Ye-zhenBAI He-lin;LUO Hong;LI Ai-li;WANG Li-dong(Department of Pathology and Pathophysiology,School of Basic Medical Sciences,Zhengzhou University,Zhengzhou,China,450001;State Key Laboratory of Esophageal Cancer Prevention&Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital,Zhengzhou University,Zhengzhou,China,450052;Guangshan People’s Hospital,Guangshan,China,465499;Linzhou Cancer Hospital,Linzhou,China,456500)
出处
《食管疾病》
2022年第1期16-19,共4页
Journal of Esophageal Diseases
基金
国家自然科学基金面上项目(81872032)。
关键词
食管癌
PCNT基因
环境因素
SNP
总生存率
esophageal cancer
PCNT gene
environmental factors
single nucleotide polymorphism
overall survival