Highly sensitive luminescent lanthanide metal-organic framework sensor for L-kynurenine

L-kynurenine(L-kyn)is a marker of prostate cancer.At present,the expensive instruments are usually applied to detect L-kyn clinically,which limits its wide application for cancer diagnosis.Herein,three lanthanide metal-organic frameworks([Ln(CHO_(2))_(3)]_(n),Ln=Eu,Gd,and Tb)were designed and obtained,and detailly characterized by single crystal X-ray diffraction(SCXRD),powder X-ray diffraction(PXRD),Fourier transform infrared spectroscopy(FT-IR),thermogravimetric analysis(TGA),and luminescence spectroscopy.Further study reveals that[Tb(CHO_(2))_(3)]_(n)is a highly selective,ultra-sensitive,of strong anti-interference,highly stable,and non-expensive sensor for prostate cancer marker L-kyn.The limit of detection(LOD)for L-kyn sensing is a highly sensitive value of 1.0×10^(−9)mol/L.Furthermore,the sensing mechanism is discussed in detail.