脂肪干细胞外泌体在增生性瘢痕中的应用及相关机制研究进展

Current research on the potential application of adipose derived stem cell exosomes in hypertrophic scars and related mechanisms

目前增生性瘢痕尚缺乏有效的治疗方法,临床发现脂肪移植可以改善瘢痕外观以及瘙痒、疼痛等症状,抑制瘢痕增生,机制与脂肪干细胞通过旁分泌参与免疫炎症反应调控有关,而脂肪干细胞外泌体在这一过程中发挥重要作用。外泌体介导干细胞与靶细胞之间的信息调控,将有望替代细胞,在增生性瘢痕治疗中具有潜在应用价值。该文综述了近年脂肪干细胞外泌体在瘢痕治疗中的应用及临床和基础研究进展,并对其临床应用前景、研究方向进行展望。

Currently,there is no effective treatment for hypertrophic scars.It has been reported clinically that fat transplantation improved scar appearance,itch,pain,as well as other symptoms,and inhibited scar hyperplasia.The mechanism may be related to the regulatory effect of adipose-derived stem cells(ADSCs)on local immune inflammatory response through paracrine,and the exosome of ADSCs may play an important role in this process.Exosomes mediate signal transduction between stem cells and target cells,which have potential application in hypertrophic scars as a substitute for cells injection.In this article,recent clinical and basic researches of ADSCs exosome in scar treatment were reviewed,its clinical application prospect and research direction were proposed.