RGS12 inhibits the progression and metastasis of multiple myeloma by driving M1 macrophage polarization and activation in the bone marrow microenvironment

Dear Editor,Multiple myeloma(MM)is a malignant plasma cancer that grows in the bone marrow and migrates through the bloodstream.Fifty-eight percent of MM patients exhibit the phenotype of hepatomegaly,and 40%have myeloma cell infiltration in the liver[1].The occurrence and migration of MM are highly associated with the bone marrow microenvironment[2].A key in the develop-ment of MM is the evasion and suppression of the host immune system.Monocyte/macrophage-lineage cells are major components of the infiltrating leukocytes in tumors.