Loss of ID3 in pancreatic cancer cells increases DNA damage without impairingMDC1 recruitment to the nuclear foci

Dear Editor,Pancreatic cancer is one of the most aggressive human cancers and is predicted to become the second leading cause of cancer-related death by the year 2030[1,2].In the United States,approximately 60,000 newly diagnosed cases and 48,000 deaths were estimated to occur in 2021[3].Because early screening is very difficult and most patients are diagnosed with advanced disease,curing pancreatic cancer patients still faces huge challenges.Accordingly,a comprehensive understanding of the pathogenesis of pan-creatic cancer is required to promote the development of efficient treatment modalities.