寡肽吸收问题的探讨

DISCUSSION ON THE ABSORPTION OF OLIGOPEPTIDES

寡肽的吸收问题一直是被关注的焦点.寡肽被摄入胃肠道(GI)环境,需要抵抗消化酶的作用,通过胃肠道和穿越肠道上皮屏障,以完整和活跃的形式到达目标器官,发挥其促进健康的特性.寡肽的吸收已不仅仅是营养学的问题,与药物的开发和临床治疗越来越密切.本文综述了寡肽肠道吸收的传统观点及近年研究的新进展、寡肽的肠道吸收机制与通路研究、口服给药的生理障碍以及克服这些障碍的方法,补充了其他吸收通道的研究.

The absorption of oligopeptides has always been the focus of attention.Once ingested into the gastrointestinal(GI)environment,oligopeptides need to resist the hydrolysis of digestive enzymes,pass through the gastrointestinal tract and cross the intestinal epithelial barrier,reach the target organs in an intact and active form,and exert their health-promoting properties.The absorption of oligopeptides is not only a problem of nutrition,but also is getting closer with the development of drugs and clinical treatment.This article summarizes the traditional view of oligopeptide intestinal absorption and the new developments in recent years,the study of oligopeptide intestinal absorption mechanism and pathways,the physiological barriers of oral administration,and the methods to overcome these barriers,as well as other absorption channels.