掌跖纤维瘤病47例临床及组织病理分析

Clinical and histopathological analysis of 47 cases of palmar and plantar fibromatosis

目的分析掌跖纤维瘤病的临床表现和组织病理特征,提高临床医师对本病的认知.方法回顾性分析2008年11月-2019年10月在陆军军医大学第一附属医院皮肤科诊治的47例掌跖纤维瘤病患者的临床及组织病理资料.结果47例患者中男29例,女18例,平均发病年龄(56.9±9.51)岁,平均病程12个月(5~36月);皮损分布左手13例、右手20例,双手受累8例、左足5例、右足1例;表现为掌跖部单发或多发结节、条索,部分患者出现掌指屈曲挛缩,活动受限,少数伴有疼痛.组织病理学上均表现为真皮中下部边界清楚的成纤维细胞及胶原增生形成的肿瘤团块,增生细胞无异形性改变.结论掌跖纤维瘤病临床较少见,临床表现结合组织病理检查是确诊的关键.

Objective To analyze the clinical manifestations and histopathological features of palmar and plantar fibromatosis in order to improve clinicians'cognition of the disease.Methods Clinical and histopathological features of 47 cases of palmar and plantar fibromatosis were retrospectively analyzed,who visited our department from November 2008 to October 2019.Results In the 47 patients,there were 29 males and 18 females,with an average onset age of 56.9±9.51 years and an average course of 12(5〜36)months.The distribution of skin lesions were as follows:left hand(n=13),right hand(n=20),both hands(n=8),left foot(n=5)and right foot(n=1);the lesions manifested as single or multiple nodules and bands in the palmar and plantar,some patients had metacarpophalangeal flexion contracture,limited movement,and a few were accompanied by pain.Histopathology showed that the tumor masses with clear boundary situated in the middle and lower dermis,constituted of fibroblasts and proliferative collagen,and the proliferative cells had no atypical changes.Conclusion Palmar and plantar fibromatosis is a rare skin disorder,thus combining the clinical features with histopathological examination is the key to arrive at a correct diagnosis.