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加味四物汤治疗痛风伴高尿酸血症患者的疗效研究 被引量:6

Therapeutic Effect of Modified Siwu Decoction in Treatment of Gout with Hyperuricemia
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摘要 目的:观察加味四物汤对痛风伴高尿酸血症患者的疗效。方法:研究纳入痛风伴高尿酸血症患者共113例,将其随机分为观察组和对照组,分析两组的总有效率、尿酸水平、尿酸达标率、骨侵蚀评分、X线骨侵蚀评分、X线关节间隙狭窄评分以及DECT尿酸盐体积。结果:治疗后,观察组的总有效率显著高于对照组(P<0.05);观察组血清尿酸水平较对照组显著降低,同时尿酸达标率显著高于对照组(P<0.05);观察组尿酸盐体积水平较对照组显著降低(P<0.05);同时,观察组CT侵蚀评分、平片侵蚀评分、关节间隙狭窄评分均较对照组显著降低(P<0.05)。结论:加味四物汤治疗痛风伴高尿酸血症,可有效降低患者血清尿酸水平,改善患者痛风关节炎。 Objective:To observe the efficacy of Modified Siwu Decoction in the treatment of gout with hyperuricemia.Methods:113 patients with gout accompanied by hyperuricemia were randomly divided into the control group(n=55)and the observation group(n=58).Both groups were given diet for gout,the control group was treated with Simiao Pill,and the observation group was treated with modified Siwu Deoction.The total effective,the level of uric acid and uric acid compliance rate,bone erosion score,X-ray bone erosion score,X-ray joint space stenosis score and DECT urate volume were analyzed and compared between the two groups after the treatment.Results:The total effective rate in the observation group was significantly higher than that in the control group(P<0.05).The serum level of uric acid was significantly lower,and uric acid compliance rate was significantly higher in the observation group than that in control group after the treatment(P<0.05).The level of urate volume was significantly lower in the observation group than that in the control group after the treatment(P<0.05).CT erosion score,plain film erosion score and joint space stenosis score were significantly lower in the observation group than those in the control group after the treatment(P<0.05).Conclusion:Modified Siwu Decoction can effectively reduce serum level of uric acid and improve gout arthritis in the treatment of gout with hyperuricemia.
作者 潘张磊 胡喜姣 王柯 宋寒冰 王瑞珩 PAN Zhanglei;HU Xijiao;WANG Ke;SONG Hanbing;WANG Ruiheng(The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China;The First Affiliated Hospital of Jiamusi University, Jiamusi 154002, China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China)
出处 《中医药学报》 CAS 2022年第4期50-53,共4页 Acta Chinese Medicine and Pharmacology
基金 黑龙江省自然科学基金优秀青年项目(YQ2020H028) 黑龙江省卫生健康委科研课题(2019-193) 黑龙江省中医药科研项目(ZHY2020-157)。
关键词 加味四物汤 痛风 高尿酸血症 Modified Siwu Decoction Gout Hyperuricemia
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