基于中医传承计算平台探索中医药治疗化疗性腹泻用药配伍规律

Analysis on medication rule of traditional Chinese medicine treating chemotherapy-induced diarrhea based on traditional Chinese medicine(TCM)inheritance computing platform system

目的:基于中医传承计算平台探索分析中医药治疗化疗性腹泻用药思路、配伍规律。方法:以“中医”、“中药”、“化疗”、“腹泻”为主题词,检索中国知网(CNKI)、万方数据库(WanFang)、维普数据库中(VIP),检索时间为自建库以来至2020年11月,筛选下载中医药治疗化疗性腹泻的临床研究文献,运用中医传承计算平台对中药的频数进行统计,并总结出核心处方及挖掘新处方。结果:共检索出相关文献145篇,筛选出目标文献57篇、包括相关处方57个;高频药物依次为白术、茯苓、党参、黄连、炙甘草等;设定置信度为0.7、支持度为10,得到12组核心配伍,聚类分析6类。结论:化疗性腹泻的中医药用药以补虚益气、利水渗湿为主,配以清热、收涩药。基于中医传承计算平台数据挖掘分析出来的方药组合及新方组合可供临床医生参考以及在基层医院推行应用。

Objective:To dig deeper into the traditional Chinese medicine treatment rules of chemotherapy-induced diarrhea with traditional Chinese medicine(TCM)inheritance computing platform system.Methods:Taking“traditional Chinese medicine”“chemotherapy”and“diarrhea”as the theme words,comprehensive search of the database of CNKI,Wanfang and VIP from its inception to November 2020 was conducted.The formulas of external treatment of traditional Chinese medicine for chemotherapy-induced diarrhea were included and the association rule,clustering and factor analysis were carried out.Results:A total of 145 papers,57 prescriptions meeting the inclusion criteria were collected,among which high-frequency drugs including Atractylodes macrocephala,Poria,Radix Codonopsis,rhizoma coptidis,Liquiritiae radix were the most commonly used.The confidence level was set as 0.7 and the support level was set as 10,12 core compatibility groups were obtained,and 6 categories were cluster analyzed.Conclusion:The principle of external treatment of chemotherapy-induced diarrhea is mainly“restore deficiency and benefit-ing qi”,“benefiting water infiltration and dampness”,“clearing heat”and“inducing astringency”.Prescription combination and new prescription combination based on traditional Chinese medicine(TCM)inheritance computing platform system can be used as reference for clinicians and applied in primary hospitals.