摘要
Diabetes mellitus(DM)is a kind of metabolic disorder characterized by chronic hyperglycemia and glucose intolerance due to absolute or relative lack of insulin,leading to chronic damage of vasculature within various organ systems.These detrimental e®ects on the vascular networks will result in the development of various diseases associated with microvascular injury.Modern optical imaging techniques provide essential tools for accurate evaluation of the structural and functional changes of blood vessels down to capillaries level,which can o®er valuable insight on understanding the development of DM-associated complications and design of targeted therapy.This review will brie°y introduce the DM-induced structural and functional alterations of vasculature within di®erent organs such as skin,cerebrum and kidneys,as well as how novel optical imaging techniques facilitate the studies focusing on exploration of these pathological changes of vasculature caused by DM both in-vivo and ex-vivo.
基金
the National Key Research and Development Program of China(Grant No.2017YFA0700501)
the National Natu-ral Science Foundation of China(Grant Nos.61860206009,81870934,62105113 and 81961138015)
China Postdoctoral Science Foundation Funded Project(Nos.BX20200138,BX20190131,2021M691145 and 2019M662633)
the Innovation Fund of WNLO.
