TPOAb、TRAb水平和甲状腺体积对Graves病患者停药后复发的预测价值

Predictive value of TPOAb,TRAb level and thyroid volume in patients with Graves disease after drug withdrawal

目的分析甲状腺激素受体(TSHR)产生抗体(TRAb)、甲状腺过氧化物酶抗体(TPOAb)和甲状腺体积对Graves病患者停药后复发的预测价值。方法选择本院2019年6月至2021年5月诊治的Graves病患者130例作为观察组,根据用药后是否复发分成复发组47例和未复发组83例。另选择同期体检健康人员130例作为对照组。检测TPOAb、TRAb水平和甲状腺体积,分析其价值。结果观察组TPOAb、TRAb水平高于对照组(P<0.05),甲状腺体积大于对照组(P<0.05)。复发组TPOAb、TRAb水平高于未复发组(P<0.05),甲状腺体积大于未复发组(P<0.05)。未复发组TPOAb、TRAb阳性率低于复发组(P<0.05)。结论TPOAb、TRAb水平和甲状腺体积影响Graves病患者停药后复发风险,其水平增加会导致Graves病患者停药后复发风险增加,建议临床密切关注。

Objective To analyze the predictive value of thyroid hormone receptor(TSHR)antibody(TRAb),thyroid peroxidase antibody(TPOAb)and thyroid volume in predicting the recurrence of patients with Graves disease after drug withdrawal.Methods A total of 130 patients with Graves disease diagnosed and treated from June 2019 to May 2021 in our hospital were selected as the observation group and divided into the recurrence group(n=47)and non-recurrence group(n=83)according to whether they recurred after medication.In addition,130 healthy persons undergoing physical examination during the same period were selected as the control group.TPOAb,TRAb levels and thyroid volume were detected,and their value was analyzed.Results The levels of TPOAb and TRAb in the observation group were higher than those in the control group(P<0.05),and the thyroid volume was larger than that in the control group(P<0.05).The levels of TPOAb and TRAb in the recurrence group were higher than those in the non-recurrence group(P<0.05),and the thyroid volume was larger than that in the non-recurrence group(P<0.05).The positive rates of TPOAb and TRAb in the non-recurrence group were lower than those in the recurrence group(P<0.05).Conclusion TPOAb,TRAb levels and thyroid volume affect the risk of recurrence in patients with Graves disease after drug withdrawal.Increased levels of them will increase the risk of recurrence in patients with Graves disease after drug withdrawal.Close clinical attention should be recommended.