胰岛素持续泵入治疗中老年糖尿病患者的疗效及安全性分析

Efficacy and safety of continuous insulin pumping in the treatment of middle-aged and elderly diabetic patients

目的分析中老年糖尿病患者胰岛素持续泵入治疗的疗效及安全性。方法选择2020年5月至2021年2月本院收治的中老年糖尿病患者100例,随机分为研究组和对照组各50例,研究组采用胰岛素持续泵入,常规组采用胰岛素皮下注射,比较两组患者治疗前后的腰臀比(Waist-hip ratio,WHR)、体质量指数(Body mass index,BMI)、生活质量和血糖控制情况,血糖达标时间、胰岛素用量、低血糖发生率。结果治疗后两组患者的WHR、BMI均低于治疗前(P<0.05),SF-36评分均高于治疗前(P<0.05),研究组患者的WHR、BMI均低于常规组(P<0.05),SF-36评分高于常规组(P<0.05);两组患者治疗后的FPG、2hPG、HbA1c均低于治疗前(P<0.05),研究组FPG、2hPG、HbA1c均低于常规组(P<0.05);研究组患者的血糖达标时间短于常规组(P<0.05),胰岛素用量少于常规组(P<0.05);治疗后,两组患者的低血糖发生率对比,差异无统计学意义(P>0.05)。结论中老年糖尿病患者胰岛素持续泵入治疗较胰岛素皮下注射治疗,可获得更好的效果,且安全性有保证。

Objective To analyze the efficacy and safety of continuous insulin pumping in the treatment of middle-aged and elderly diabetic patients.Methods A total of 100 middle-aged and elderly diabetic patients admitted to our hospital from May 2020 to February 2021 were selected and divided into the conventional group and study group,with 50 cases in each group.The study group was treated with continuous insulin pumping and the conventional group was treated with insulin subcutaneous injection.The WHR and BMI,the quality of life,blood glucose control levels,the time of blood glucose reaching standard,insulin dosage and incidences of hypoglycemia were compared between the two groups.Results After treatment,the WHR and BMI of the two groups were lower than those before treatment(P<0.05),and SF-36 score was higher than that before treatment(P<0.05).The WHR and BMI of the study group were lower than those of the conventional group(P<0.05),and the SF-36 score was higher than that of the conventional group(P<0.05).After treatment,FPG,2hPG and HbA1c in two groups were lower than those before the treatment(P<0.05),and FPG,2hPG and HbA1c in study group were lower than those in conventional group(P<0.05).In the study group,the time of blood glucose reaching standard was shorter than that in the conventional group(P<0.05),and the dosage of insulin was lower than that in the conventional group(P<0.05).After treatment,there was no significant difference in the incidence of hypoglycemia between the two groups(P>0.05).Conclusion In the treatment of middle-aged and elderly patients with diabetes mellitus,continuous infusion insulin pumping has a better effect than subcutaneous injection of insulin,and its safety is guaranteed.