STIM1蛋白、尿蛋白、GST在急性缺血性脑梗死中的表达及临床意义

Expression and clinical significance of STIM1 protein,urine protein and GST in acute ischemic cerebral infarction

目的研究基质相互作用因子1(STIM1)蛋白、尿蛋白、谷胱甘肽S-转移酶(GST)在急性缺血性脑梗死中的表达及临床意义。方法收集2018年5月至2020年10月郑州市金水区总医院收治的127例急性缺血性脑梗死患者作为研究组,同时根据临床神经功能缺损程度评分标准将患者分为:轻度组(40例)、中度组(49例)和重度组(38例),另选取82例同时间段行健康体检者作为健康组。比较两组以及不同程度急性缺血性脑梗死患者STIM1蛋白、尿蛋白、GST水平。分析影响急性缺血性脑梗死患者预后的独立危险因素。结果研究组STIM1蛋白、尿蛋白高于对照组,GST水平低于对照组,差异均有统计学意义(P<0.05)。不同程度急性缺血性脑梗死患者STIM1蛋白、尿蛋白:重度组>中度组>轻度组,GST:重度组<中度组<轻度组,差异均有统计学意义(P<0.05)。性别、吸烟、平均体质量不是影响患者预后的因素(P>0.05);年龄、STIM1、尿蛋白、GST、病情程度、家族史为影响急性缺血性脑梗死患者预后的单因素(P<0.05)。多因素Logistic回归模型分析显示,年龄、STIM1、尿蛋白、GST、病情程度、家族史为影响急性缺血性脑梗死患者预后的独立危险因素(P<0.05)。结论STIM1蛋白、尿蛋白及GST水平变化可在一定程度上对急性缺血性脑梗死患者预后产生影响,临床可考虑将其应用于急性缺血性脑梗死检测中。

Objective To study the expression of stromal interaction molecule 1(STIM1)protein,urine protein and glutathione S-transferase(GST)in acute ischemic cerebral infarction and their clinical significance.Methods 127 patients with acute ischemic cerebral infarction admitted to Jinshui District General Hospital of Zhengzhou from May 2018 to October 2020 were collected as the study group,and the patients were divided into the mild group,the moderate group,and the severe group according to the clinical neurological impairment scoring standard,another 82 patients who underwent physical examination at the same period were selected as the healthy group.The levels of STIM1 protein,urine protein and GST were compared between the two groups and patients with different degrees of acute ischemic cerebral infarction.The independent risk factors that affected the prognosis of patients with acute ischemic cerebral infarction were analyzed.Results STIM1protein and urine protein in the study group were higher than those in the control group,and the GST level was lower than that in the control group,the difference was statistically significant(P<0.05).STIM1 protein and urine protein in patients with different degrees of acute ischemic cerebral infarction:the severe group>the moderate group>the mild group,GST:the severe group<the moderate group<the mild group,the differences were statistically significant(P<0.05).Gender,smoking,and average body weight were not the factors affecting the prognosis of patients(P>0.05).Age,STIM1,urine protein,GST,degree of disease and family history were the single factors influencing the prognosis of patients with acute ischemic cerebral infarction(P<0.05).Multivariate logistic regression model analysis showed that age,STIM1,urine protein,GST,disease severity,and family history were independent risk factors that affected the prognosis of patients with acute ischemic cerebral infarction(P<0.05).Conclusion The changes of STIM1 protein,urinary protein and GST levels can affect the prognosis of patients with acute ischemic cerebral infarction to a certain extent,and it can be considered for clinical application in the detection of acute ischemic cerebral infarction.