不同Ig类型多发性骨髓瘤患者血脂测定及与预后的关系

Determination of blood lipids in patients with multiple myeloma of different Ig types and its relationship with prognosis

目的探讨不同Ig类型多发性骨髓瘤(MM)患者血脂测定及与预后的关系。方法分析2017年1月至2021年3月皖北煤电集团总医院血液科83例MM患者,选取同期35名健康体检者为对照组。分析不同Ig类型MM患者血脂指标与预后的关系。结果观察组HDL-C、LDL-C及TC显著低于对照组,差异有统计学意义(P<0.05);IgG型、IgA型HDL-C、LDL-C、TC均显著低于轻链型,差异有统计学意义(P<0.05);IgD型、IgM型HDL-C、LDL-C均显著低于轻链型,差异有统计学意义(P<0.05);IgG型、IgA型、轻链型、IgD型、IgM型患者预后不良占比分别为68.57%、59.26%、43.75%、33.33%、0.00(P<0.05);Pearson相关分析表明,不同Ig类型MM患者HDL-C、LDL-C、TC与患者预后呈正相关(P<0.05)。结论不同Ig类型MM患者血脂水平差异较大,且低血脂水平MM患者预后较差。

Objective To explore the relationship between blood lipids and prognosis in patients with multiple myeloma(MM)of different Ig types.Methods A retrospective analysis of 83 MM patients in the Department of Hematology,Wanbei Coal and Electricity Group General Hospital from January 2017 to March 2021,during the same period,35 healthy subjects were selected as the control group.The relationship between blood lipid indicators and prognosis of patients with different Ig types of MM was analyzed.Results The HDL-C,LDL-C and TC levels in the observation group were significantly lower than those in the control group(P<0.05).IgG type,IgA type HDL-C,LDL-C and TC were significantly lower than light chain type(P<0.05).IgD type,IgM type HDL-C,LDL-C are significantly lower than light chain type(P<0.05).The proportion of IgG,IgA,light chain,IgD and IgM patients with poor prognosis was 68.57%,59.26%,43.75%,33.33%and 0.00 respectively(P<0.05);Pearson correlation analysis showed that HDL-C,LDL-C and TC in patients with different Ig types of MM were positively correlated with the patient’s prognosis(P<0.05).Conclusion The blood lipid levels of MM patients with different Ig types are quite different,and the prognosis of MM patients with lower blood lipid levels is poor.