过敏性紫癜患儿免疫球蛋白、补体水平及抗核抗体检测分析

Detection and analysis of immunoglobulin,complement levels and antinuclear antibodies in children with Henoch-Schonlein purpura

目的探讨过敏性紫癜(HSP)患儿免疫球蛋白、补体水平及抗核抗体检测变化。方法选取2019年2月至2021年3月在阜南县人民医院儿内科接受治疗的92例HSP患儿为研究对象。于同期,选取健康儿童41例为对照组。比较两组免疫球蛋白(IgA、IgG、IgM)、补体水平(C3、C4)及抗核抗体的差异,评估IgA、IgA/C3对HSP的诊断价值。结果观察组IgA水平显著高于对照组,差异有统计学意义(P<0.05);两组IgG、IgM水平比较差异无统计学意义(P>0.05)。两组C3、C4比较差异无统计学意义(P>0.05);观察组IgA/C3显著高于对照组,差异有统计学意义(P<0.05)。观察组抗核抗体阳性率显著高于对照组,差异有统计学意义(P<0.05)。ROC曲线分析显示,IgA、IgA/C3及两项联合对HSP的诊断具有一定价值(P<0.05)。结论HSP患儿体内IgA、IgA/C3较高,抗核抗体检测均呈阳性,且IgA、IgA/C3对HSP发生具有一定诊断价值。

Objective To investigate the changes in the levels of immunoglobulin,complement and antinuclear antibodies in children with Henoch-Schonlein purpura(HSP).Methods A total of 92 children with HSP who were treated at the Department of Pediatrics of Funan County People’s Hospital from February 2019 to March 2021 were selected as the research objects.During the same period,41 healthy children were selected as the control group.The differences in immunoglobulin(IgA,IgG,IgM),complement levels(C3,C4)and antinuclear antibodies were compared between the two groups,and the diagnostic value of IgA and IgA/C3 in HSP was evaluated.Results The level of IgA in the observation group was significantly higher than that in the control group(P<0.05).There was no significant difference in the levels of IgG and IgM between the two groups(P>0.05).There was no significant difference in C3 and C4 between the two groups(P>0.05).The IgA/C3 in the observation group was significantly higher than that in the control group(P<0.05).The positive rate of antinuclear antibodies in the observation group was significantly higher than that in the control group(P<0.05).The ROC curve analysis showed that IgA,IgA/C3 and the combination of the two have a certain value in the diagnosis of HSP(P<0.05).Conclusion Children with HSP have higher levels of IgA and IgA/C3,and the antinuclear antibodies are all positive,and IgA and IgA/C3 have certain diagnostic value for the occurrence of HSP.