肿瘤相关成纤维细胞治疗策略及其递送系统研究进展

Recent advances on cancer-associated fibroblasts treatment strategies and delivery systems

肿瘤组织中大量的肿瘤相关成纤维细胞(cancer-associated fibroblasts, CAFs)为肿瘤的发展构建了良好的环境。CAFs不仅可以抑制免疫细胞的活化和功能,还能阻止药物与免疫细胞向肿瘤组织的深层渗透,从而降低肿瘤治疗效果。通过调控CAFs或克服其屏障作用抑制肿瘤是肿瘤治疗的新手段。设计纳米载体靶向调控CAFs以抑制肿瘤进展,促进药物穿过CAFs屏障以提高肿瘤部位的药物蓄积是目前肿瘤治疗研究的热点。基于此,本文对纳米载体用于以CAFs为靶点的肿瘤治疗研究进展进行综述,以期为肿瘤临床治疗提供参考。

A large number of cancer-associated fibroblasts(CAFs) in tumor tissues create a favorable environment for the development of tumor. CAFs inhibit immune cells activation and viability by cytokine secretion, and CAFs prohibit drugs and immune cells infiltration by producing extracellular matrix to weaken cancer treatment efficacy. Regulating CAFs or overcoming CAFs barriers are new strategies for cancer therapy.Hence, designing nano-carriers for regulating CAFs to suppress tumor progression or promoting drug delivery to tumor site by overcoming CAFs barriers has attracted much attention. Therefore, this manuscript reviewed the recent progresses of nano-carriers for CAFs-targeting cancer therapies, in order to provide a reference for clinical cancer treatment.