中性粒细胞死亡在急性肺损伤中的作用

The role of neutrophil death in acute lung injury

急性肺损伤(acute lung injury,ALI)是临床常见的危重病,严重时会发展成急性呼吸窘迫综合征,甚至导致死亡,目前尚无有效的治疗方法。在不同病理生理条件下,中性粒细胞呈现多种不同的死亡形式,如中性粒细胞外诱捕网、铁死亡、焦亡、凋亡、自噬、坏死及坏死性凋亡等。不同形式的中性粒细胞死亡在ALI的发生、发展进程中发挥着不同的作用。文章对中性粒细胞死亡的不同形式及其在ALI中的作用进行综述,以期为探索ALI的发生机制及防治策略提供新思路和新靶点。

Acute lung injury(ALI)is a common clinically critical illness that can develop into acute respiratory distress syn‑drome and even lead to death.Currently,there is no effective treatment method.In different pathophysiological conditions,neutrophils manifest many different forms of death,such as neutrophil extracellular traps,ferroptosis,pyroptosis,apoptosis,autophagy,necrosis and necroptosis.Different forms of neutrophil death play distinct roles in the occurrence and development of ALI.This review summa‑rizes the different forms of neutrophil death and their role in ALI and aims to provide new ideas and new targets for exploring the mech‑anism and prevention and treatment strategies of ALI.