深圳市罗湖乙肝综合防治示范区劳务工人乙肝病毒感染状况调查

Hepatitis B virus infection among 5493 migrant workers in Shenzhen city’s Luohu Demonstration Zone for comprehensive hepatitis B prevention and treatment

目的了解深圳市罗湖区乙型肝炎(以下简称乙肝)综合防治示范区内≥18岁劳务工人乙肝病毒感染状况,为深圳市劳务工人乙肝病毒的防治提供科学依据。方法选取罗湖辖区范围内于2019年4月-2020年6月间进行健康体检的劳务工人,在取得知情同意后完成问卷调查并采集肘静脉血液,采用酶联免疫吸附实验检测血清乙肝表面抗原和抗体。结果共收集到5493名劳务工人血液标本及调查问卷,乙肝表面抗原(HBsAg)阳性率为6.54%,乙肝表面抗体(抗-HBs)阳性率为60.37%,不同年龄、文化程度、职业、户籍来源以及乙肝疫苗接种史比较,HBsAg和抗-HBs阳性率差异均有统计学意义,将2项乙肝血清标志物中单因素分析有意义的变量采用二元logistic回归分析,结果发现接种乙肝疫苗是HBsAg感染的保护性因素,文化程度初中及中以下、年龄30~49岁是危险性因素;而接种疫苗、<30岁人群和户籍为华东地区抗-HBs阳性率高于其他人群。结论深圳市罗湖乙肝综合防治示范区乙肝病毒感染率较国家"十一五"期间有所降低,但还应加强重视<20岁年龄组、户籍来源为西南、东北和西北以及未接受过乙肝疫苗接种人群的乙肝防治工作。

Objective To examine the prevalence of hepatitis B virus(HBV)infection among migrant workers in Luohu district of Shenzhen city for providing evidences to HBV infection prevention in the workers.Methods A questionnaire survey and serum hepatitis B surface antigen(HBsAg)and antibody(anti-HBs)detections with enzyme-linked immunosobent assay(ELISA)were conducted among 5493 migrant workers in Shenzheng city′s Luohu demonstration zone for comprehensive prevention and control of hepatitis B(HB)when the workers had their physical examinations between April 2019 and June 2020.Results For all the workers,the positive rate was 6.54%and 60.37%for serum HBsAg and antiHBs;the positive rate of both HBsAg and anti-HBs differed significantly by age,education,occupation,registered residence,and history of HBV vaccination.The results of binary logistic regression analysis on significant influencing factors of serum HBsAg and anti-HBs identified with univariate analysis demonstrated that inoculation of HBV vaccine is a protective factor against HBsAg positive;while,with the education of junior high school and lower and aged 30-49 years are risk factors for HBsAg positive;the results also indicated that the workers having received HBV vaccination,aged less than 30 years,and with a registered residence in East China were more likely to be serum anti-HBs positive compared to other migrant workers.Conclusion The prevalence of HBV infection decreased in comparison to that ten years ago among migrant workers in Shenzhen city′s Luohu demonstration zone for comprehensive HBV infection prevention and treatment but the prevention of HBV infection still needs to be strengthened in the unvaccinated migrant workers younger than 20 years and in those from southwest,northeast and northwest region of China.