鳖甲煎丸联合医用三氧自体血回输治疗肝硬化疗效观察

Effect of Biejiajian Pills Combined with Medical Ozone Autologous Blood Transfusion in the Treatment of Liver Cirrhosis

目的观察鳖甲煎丸联合医用三氧自体血回输治疗肝硬化的临床疗效。方法选取2019年1月—2019年3月本院住院的肝硬化患者48例,随机分为2组,各24例。对照组采用鳖甲煎丸治疗,治疗组采用鳖甲煎丸联合医用三氧自体血回输治疗。12周后,比较2组患者治疗前后透明质酸(hyaluronic acid,HA)、III型前胶原氨端肽(procollagen III N-terminal peptide,PIIINP)、IV型胶原(collagen IV,CIV)、层粘蛋白(laminin,LN)及肝脏硬度测定(liver stiffness measurement,LSM)水平。结果治疗后,治疗组HA、CIV、LN、LSM水平显著低于对照组(P<0.05)。结论鳖甲煎丸联合医用三氧自体血回输治疗具有明显抗纤维化作用,可明显减缓肝硬化病情进展。

Objective To observe the clinical effects of Biejiajian pills combined with medical ozone autologous blood transfusion in the treatment of liver cirrhosis.Methods From January 2019 to March 2019,48 patients with liver cirrhosis hospitalized in our hospital were selected and randomly divided into two groups,with 24 patients in each group.The control group was treated with Biejiajian pills,while the treatment group was treated with Biejiajian pills combined with medical ozone autologous blood transfusion.After 12 weeks,the levels of hyaluronic acid(HA),procollagen III N-terminal peptide(PIIINP),collagen IV(CIV),laminin(LN)and liver stiffness measurement(LSM)were compared between the two groups before and after treatment.Results After treatment,the levels of HA,CIV,LN and LSM were significantly lower than those in the control group(P<0.05).Conclusion Biejiajian pills combined with medical ozone autologous blood transfusion has an obvious anti-fibrotic effect,which could significantly slow down the progress of liver cirrhosis.