加减归肾丸对卵巢早衰患者的辅助治疗临床研究

Clinical study on adjuvant treatment of modified Guishen Wan on patients with premature ovarian failure

目的:探讨加减归肾丸对卵巢早衰患者的辅助治疗临床研究。方法:将2016年1月-2020年12月在三明市第一医院生殖科治疗的60例卵巢早衰患者随机分为两组,每组30例,对照组使用常规西医(戊酸雌二醇片+黄体酮胶囊)治疗,在此基础上,观察组使用加减归肾丸治疗,对比两组的临床疗效、中医证候积分变化、血清激素水平变化。结果:观察组治疗有效率显著高于对照组(P<0.05);两组治疗前闭经或月经量少、腰膝酸软、头晕耳鸣、五心烦热、潮热盗汗等中医证候积分相比差异无统计学意义(P>0.05),观察组治疗后闭经或月经量少、腰膝酸软、头晕耳鸣、五心烦热、潮热盗汗等中医证候积分显著低于对照组(P<0.05);两组治疗前促黄体生成素(Luteinizing Hormone,LH)、促卵泡生成激素(Follicle Stimulating Hormone,FSH)、雌二醇(Estradiol,E2)水平相比差异无统计学意义(P>0.05),观察组治疗后LH、FSH显著低于对照组,E2显著高于对照组(P<0.05)。结论:加减归肾丸对卵巢早衰患者的辅助治疗临床效果显著,能有效减轻中医证候,调整激素水平,维持卵巢正常生理功能,抑制卵巢早衰,具有积极的临床意义。

Objective:To explore the clinical study of adjuvant treatment of modified Guishen Wan(加减归肾丸)in the treatment of premature ovarian failure.Methods:60 cases of premature ovarian failure patients treated in the reproductive department of Sanming First Hospital from January 2016 to December 2020 were randomly divided into two groups.The control group was treated with conventional Western medicine,on this basis,the observation group was treated with modified Guishen Wan,and the clinical efficacy,TCM syndrome score change and serum hormone level change of the two groups were compared.Results:The effective rate in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the scores of TCM syndromes in the observation group were significantly lower than those in the control group(P<0.05).After treatment,LH and FSH in the observation group were significantly lower than those in the control group,and E2 in the observation group was significantly higher than that in the control group(P<0.05).Conclusion:Modified Guishen Wan has significant clinical effect in the adjuvant treatment of premature ovarian failure patients,which can effectively reduce the syndrome,adjust the hormone level,maintain the normal physiological function of the ovary,and it has positive clinical significance.