针药结合对非酒精性脂肪肝临床疗效的Meta分析

A meta-analysis of the clinical efficacy of acupuncture plus medicine on non-alcoholic fatty liver disease

目的:系统评价针刺结合药物治疗非酒精性脂肪肝的临床疗效。方法:检索中国知网、万方数据库、维普数据库从建库至2021年3月以针刺联合药物(包括中药和西药)治疗非酒精性脂肪肝的临床研究文献,根据纳入标准筛查文献,进行资料提取,并进行偏倚风险评价,应用RevMan 5.3软件对纳入的研究进行Meta分析。结果:共纳入19项随机对照试验研究,合计815例非酒精性脂肪肝的患者。试验组与对照组在临床总有效率、谷丙转氨酶、谷草转氨酶、三酰甘油、胆固醇水平方面比较,差异具有显著的统计学意义(P<0.05)。结论:针刺结合药物治疗非酒精性脂肪肝疗效优于单纯药物,但由于纳入研究的数量少、质量等级不高,今后仍需开展大样本、高质量的随机对照试验以提高本研究结果的可靠性。

Objective:To systematically evaluate the clinical efficiency of acupuncture plus mindicien on non-alcoholic fatty liver disease.Methods:From the establishment of the database to March 2021,the clinical research literature on the treatment of non-alcoholic fatty liver by acupuncture plus medicines(including TCM and Western medicine)in the CNKI,Wanfang and VIP databases was searched.According to the inclusion criteria,the literature was screened,data extraction and bias risk evaluation were performed,and the included studies were meta-analyzed using RevMan 5.3 software.Results:A total of 19 randomized controlled trials involving 815 patients with non-alcoholic fatty liver disease were included.Comparing the acupuncture plus medicine group and single medicine group,there were signifcantly statistical differences in the total efficiency,ALT,AST,TG and TC levels.Conclusion:Acupuncture plus medicine therapy is more effective than medicine therapy alone on non-alcoholic fatty liver disease.However,due to the small number and low quality of included studies,large-sample and high-quality randomized controlled trials were still needed in the future to improve the reliability of the results of the study.