维生素D与产科母婴结局的研究进展

Research progress of vitamin D and obstetric maternal and infant outcomes

维生素D是一种脂溶性类固醇衍生物,对维持人体正常生理功能非常重要,在胚胎发生,骨骼发育和钙稳态中起着重要作用。全球人群维生素D普遍缺乏,妊娠期维生素D缺乏的患病率明显上升,同时伴随着不良的母婴结局,如妊娠期糖尿病、子痫前期、早产、低出生体质量等。目前,对于补充维生素D是否有助于改善母儿预后,以及维生素D是否是不良妊娠结局的病因或标志物,尚无统一定论。现综述有关妊娠期维生素D水平与母婴结局的最新研究进展。

Vitamin D is a fat soluble steroid derivative,which is very important to maintain human normal physiological function.It plays an important role in embryogenesis,bone development and calcium homeostasis.Vitamin D deficiency is widespread in the world,and the prevalence of vitamin D deficiency during pregnancy is also significantly increased,accompanied by adverse maternal and neonatal outcomes,such as gestational diabetes mellitus,preeclampsia,premature delivery,and low birth weight.At present,there is no consensus on whether vitamin D supplementation is helpful to improve the prognosis of mothers and infants,and whether vitamin D is the etiology or marker of adverse pregnancy outcome.This paper reviews the latest research progress on the relationship between vitamin D level during pregnancy and maternal and infant outcomes.