摘要
Mammalian target of rapamycin(m TOR) is a conserved Ser/Thr kinase that includes m TOR complex(m TORC) 1 and m TORC2. The m TOR pathway is activated in viral hepatitis, including hepatitis B virus(HBV) infection-induced hepatitis.Currently, chronic HBV infection remains one of the most serious public health issues worldwide. The unavailability of effective therapeutic strategies for HBV suggests that clarification of the pathogenesis of HBV infection is urgently required. Increasing evidence has shown that HBV infection can activate the m TOR pathway, indicating that HBV utilizes or hijacks the m TOR pathway to benefit its own replication. Therefore, the m TOR signaling pathway might be a crucial target for controlling HBV infection. Here, we summarize and discuss the latest findings from model biology research regarding the interaction between the m TOR signaling pathway and HBV replication.
基金
This work was supported by a scholarship from the Medical Faculty of University Duisburg-Essen
the Foundation for Innovative Research Groups of Hubei Provincial Natural Science Foundation(2018CFA031)
Hubei Province’s Outstanding Medical Academic Leader Program,the National Natural Science Foundation of China(No.81974079)
the Key R&D Program of Hunan province(No.2020SK30291)。
