摘要
Dear Editor,Omsk hemorrhagic fever virus(OHFV)belongs to the tickborne virus group within Flavivirus,in Flaviviridae family(Holbrook et al.2005)which consists of several important human pathogens including tick-borne encephalitis virus(TBEV),Powassan virus(POWV),Louping ill virus(LIV),Langat virus(LGTV)and Kyasnaur Forest disease virus(KFDV)(Yoshii and Holbrook 2009).OHFV is an enveloped virus containing a single-stranded positive-sense RNA genome of approximately 11,000 nucleotides.The genome has a single open reading frame,which encodes three structural proteins[capsid(C),pre-membrane(prM)or membrane(M),and envelop(E)]and seven non-structural proteins(NS1,NS2a,NS2b,NS3,NS4a,NS4b and NS5)between the 5'untranslated region(UTR)and 3'UTR(Chambers et al.1990).
基金
This work was supported by the National Major Science and Technology Project(2018ZX10711001-006)
the Wuhan Science and Technology Project(2018201261638501)。
