摘要
Dear Editor,Human enteroviruses(HEVs)comprise polioviruses,coxsackieviruses,echoviruses,rhinoviruses,and the enterovirus subgroups and belong to the genus Enterovirus in the family Picornaviridae(Baggen et al.2018).The HEV genome was thought to contain a single open reading frame(ORF)encoding one polyprotein,which was post-translationally processed into structural capsid proteins(VP1-4)and non-structural accessory proteins(2A,2B,2C,3A,3B,3C,3D)(Baggen et al.2018).Recently,we and others,have identified an additional upstream ORF(Guo et al.2019a;Lulla et al.2019)(ORF2/uORF).
基金
This work was supported in part by funding from the National Natural Science Foundation of China(81772183 and 31800150)
the Department of Science and Technology of Jilin Province(No.20190304033YY and 20180101127JC)
the open project of Key Laboratory of Organ Regeneration and Transplantation,Ministry of Education
the Program for JLU Science and Technology Innovative Research Team(2017TD-08)
Fundamental Research Funds for the Central Universities。
