微RNA在异位妊娠发病机制及早期检测中的研究进展

Research Progress of MicroRNAs in Pathogenesis and Early Detection of Ectopic Pregnancy

异位妊娠是一种常见的妇科急腹症,也是孕早期孕妇死亡的主要原因。目前异位妊娠的发病机制尚不明确,且在妊娠早期异位妊娠与宫内孕特别是宫内孕发育不良鉴别困难,同时异位妊娠早期检测指标缺乏特异性,这些因素均可导致患者病情延误或宫内妊娠不必要丢失。因此,深入研究异位妊娠的发病机制,寻找异位妊娠早期检测指标,可以为异位妊娠早期诊断提供依据。微RNA(miRNA)可稳定存在于外周血中,且部分miRNA与妊娠密切相关,因此,深入研究特异性较高的miRNA在异位妊娠中的作用并将其作为异位妊娠的早期检测指标具有一定临床意义。

Ectopic pregnancy is a common gynecologic acute abdomen,which is the main cause of death in early pregnancy.At present,the pathogenesis of ectopic pregnancy is not clear,and in the early pregnancy,it is difficult to distinguish ectopic pregnancy from intrauterine pregnancy,especially intrauterine pregnancy with dysplasia.Besides,the early detection indexes of ectopic pregnancy are lack of specificity.All of these factors can lead to the delay of patients′condition or the unnecessary loss of intrauterine pregnancy.Therefore,in-depth research on the pathogenesis and exploration of the early detection indicators of ectopic pregnancy can provide the basis for early diagnosis of ectopic pregnancy.MicroRNA(miRNA)can stably exist in peripheral blood,and some miRNAs are closely related to pregnancy.Therefore,it is of certain clinical significance to further study the role of highly specific miRNA in ectopic pregnancy and take it as an early detection index of ectopic pregnancy.