非酒精性脂肪性肝病相关分子机制的研究进展

Research Progress in Molecular Mechanism of Non-alcoholic Fatty Liver Disease

非酒精性脂肪性肝病(NAFLD)已成为目前全球最流行的肝病之一,其发生与不良生活方式、胰岛素抵抗、遗传以及代谢应激密切相关。NAFLD发生的潜在机制复杂,涉及各种细胞介质及相关信号通路、内质网应激以及细胞自噬等病理过程。从单纯性脂肪肝到非酒精性脂肪性肝炎,再到肝纤维化和晚期肝硬化等,目前临床可直接用于治疗NAFLD的药物较少。因此,了解NAFLD发生的分子机制及相关信号通路在其发展过程中的作用,对临床治疗具有重要意义。

Non-alcoholic fatty liver disease(NAFLD)has become one of the most popular liver diseases in the world.The occurrence of NAFLD is closely related to bad lifestyle,insulin resistance,heredity and metabolic stress.The underlying mechanism of NAFLD is complex,involving a variety of cellular mediators and related signal pathways,endoplasmic reticulum stress and cell autophagy and other pathological processes.From simple fatty liver to non-alcoholic steatohepatitis,and then to liver fibrosis and end-stage liver cirrhosis,there are few drugs that can be directly used to treat NAFLD.Therefore,it is of great significance for the clinical treatment to understand the molecular mechanism of NAFLD and the role of related signal pathways in its development.