宫颈癌上皮-间充质转化相关长链非编码RNA的研究进展

Research Progress of Long Non-coding RNA Related with Epithelial-mesenchymal Transformation in Cervical Cancer

宫颈癌是女性生殖系统常见的恶性肿瘤之一,部分患者因复发、转移而预后较差,严重影响女性的身心健康。上皮-间充质转化(EMT)通过改变细胞间黏附力、细胞顶端基底极性及细胞游走性,在与宫颈癌进展相关的侵袭及转移过程中发挥重要作用。部分长链非编码RNA(lncRNA)在宫颈癌组织中异常表达且与促进肿瘤进展有关的EMT过程密切相关,为研究宫颈癌的侵袭、转移机制提供了新方向。深入研究lncRNA在宫颈癌EMT过程中的具体作用机制可为宫颈癌的治疗提供新思路。

Cervical cancer is one of most common malignant tumors in female reproductive system.Some patients have poor prognosis due to recurrence and metastasis,which seriously affects the women′s physical and mental health.Epithelial-mesenchymal transformation(EMT)plays an important role in the invasion and metastasis progress of cervical cancer by changing the adhesion between adjacent cells,basal polarity of cell tip and the mobility of cells.Some long non-coding RNA(lncRNA)are abnormally expressed in cervical cancer tissues and are closely related to the EMT process that promotes tumor progression,which will provide a new direction for the research on invasion and metastasis mechanism of cervical cancer.In-depth study of the specific role and precise mechanism of lncRNA in EMT of cervical cancer will generate new ideas for the treatment of cervical cancer.