抑郁情绪促进前列腺肿瘤生长相关机制的研究进展

Research Progress in Mechanisms of Depression Promoting Prostate Tumor Growth

前列腺肿瘤是男性泌尿系统常见肿瘤之一,病因目前尚未明确。抑郁情绪包括情绪低落、焦虑等,而前列腺肿瘤患者普遍伴有长期的抑郁情绪,严重者甚至罹患抑郁症。长期抑郁可促进前列腺肿瘤生长,导致患者预后较差。但目前关于抑郁情绪促进前列腺肿瘤生长机制的研究仍局限于交感神经或各种机制引起的前列腺肿瘤免疫微环境改变方面。因此,未来仍需进一步寻找抑郁情绪促进前列腺肿瘤生长的具体靶点,为前列腺肿瘤伴抑郁情绪患者的诊治提供新思路。

Prostate tumor is one of the common tumors in male urinary system,and its pathogenesis is not clear.Depression includes depressed mood,anxiety and other negative emotions.Prostate tumor patients are generally accompanied by long-term depressed mood,and in severe cases the patients suffer from depression.Long term depression can promote the growth of prostate tumor and lead to poor prognosis.However,the research on the mechanism of depression promoting prostate tumor growth is still limited to the changes of prostate tumor immune microenvironment caused by sympathetic nerves or other common mechanisms.Future research still needs to further discover the specific targets of depression promoting prostate tumor growth,so as to facilitate the diagnosis and treatment of the patients with prostate tumor with depression.