柴芩承气汤灌肠治疗肝胆湿热型急性胰腺炎的临床观察

The effects of retention enema with the Chaiqin Chengqi decoction on acute pancreatitis of hepatobiliary damp-heat type

目的:观察柴芩承气汤保留灌肠联合常规西医治疗急性胰腺炎的临床疗效。方法:选取武汉市中医医院88例胰腺炎患者,按随机数字表法分为对照组和观察组各44例。对照组给予常规西医治疗,观察组在对照组基础上给予柴芩承气汤保留灌肠,治疗7天后比较两组的疗效,症状体征缓解时间,白细胞(White Blood Cell,WBC)、血清淀粉酶(Blood Amylase,AMS)、脂肪酶(Lipase,LPS)及C反应蛋白(C-reactiveProtein,CRP)水平情况。结果:治疗7天后,观察组总有效率高于对照组(P=0.016);观察组腹胀、腹痛缓解时间,肠鸣音及排便恢复时间与住院时间均小于对照组(P<0.01);治疗后,两组WBC细胞、血清AMS、血清LPS及CRP指标均较入院时下降,且观察组降低程度高于对照组,差异有统计学意义(P<0.01)。结论:柴芩承气汤保留灌肠联合西医治疗急性胰腺炎临床疗效显著,可缩短症状体征缓解时间,有效改善机体炎症相关指标,无不良反应。

Objective:To observe clinical effects of retention enema with the Chaiqin Chengqi decoction(柴芩承气汤)plus conventional Western medicine on acute pancreatitis.Methods:88 cases were selected and randomly divided into the control group and the observation group according to the random number table method,with 44 cases in each group.The control group was given conventional Western medicine,and the observation group was given conventional Western medicine treatment plus retention enema with the Chaiqin Chengqi decoction.The treatment lasted for 7 days.Results:After 7 days of treatment,the total efficiency in the observation group was higher than the control group(P=0.016).The remission time of abdominal distension and abdominal pain,the recovery time of bowel sounds and defecation,and hospitalization time in the observation group were better than the control group(P<0.01).After treatment,the indexes of WBC,blood AMS,LPS and CRP in the two groups were decreased compared with those at admission,and the degree of reduction in the observation group was higher than the control group(P<0.01).Conclusion:Retention enema with the Chaiqin Chengqi decoction plus conventional Western medicine shows significantly clinical effect on acute pancreatitis,can shorten the remission time of symptoms and signs,effectively improve the body’s inflammation-related indicators,without adverse reactions.