肥胖型2型糖尿病及其C反应蛋白与中医证型相关性分析

Correlation analysis of TCM syndrome type and C-reaction protein in obese type 2 diabetes mellitus patients

目的:回顾性分析肥胖型2型糖尿病(Type 2 Diabetes Mellitus,T2DM)患者及其C反应蛋白(C-reaction Protein,CRP)与中医证型的相关性并探究其临床防治重点。方法:选取188例肥胖型T2DM患者为研究对象,采集四诊信息进行中医辨证分型,对其CRP水平及中医证型进行回顾性分析,统计各个中医证型所占例数,并探讨其防治重点。结果:188例患者中痰(湿)热互结34例、阴阳两虚23例、气阴两虚36例、脾虚湿盛53例、气虚血瘀42例,其中脾虚湿盛型、气虚血瘀型占比较高;5组证型患者空腹血糖(Glucose,GLU)、餐后2小时血糖(2 hours Postprandial Blood Glucose,2 h PBG)、身体质量指数(Body Mass Index,BMI)差异无统计学意义(P> 0.05);5组证型中,气虚血瘀型患者血清CRP最高,与其他组间比较差异有统计学意义(P <0.05)。结论 :T2DM的发病更加趋向于虚实夹杂,以虚为本、实为标;气虚血瘀型患者血清CRP较高,因此疏通气血、控制炎症,在肥胖型T2DM的治疗中应给予足够的重视。

Objective:To retrospectively analyze the correlation between the type 2 diabetes mellitus(T2DM)and its C-reaction Protein(CRP)and the syndrome of TCM and explore its clinical prevention and treatment emphasis.Methods:188 cases of obese T2DM patients were selected as the research objects,and the information of four diagnostic methods was collected for TCM syndrome differentiation.The CRP level and TCM syndrome type were analyzed retrospectively,and the number of each TCM syndrome type was counted,and the key points of prevention and treatment were discussed.Results:Among the 188 patients,34 cases had phlegm-heat mutual junction,23 cases had deficiency of Yin and Yang(阴阳),36 cases had deficiency of Qi(气)and Yin,53 cases had deficiency of spleen dampness and blood stasis,and 42 cases had deficiency of Qi and blood stasis,among which the proportion of dampness and blood stasis with spleen deficiency was higher.There was no significant difference in GLU、2 h PBG、BMI among the 5 groups(P>0.05).Among the 5 syndromes,the serum CRP of patients with Qi deficiency and blood stasis was the highest,which was statistically significant compared with other groups(P<0.05).Conclusion:The incidence of T2DM is more likely to be mixed with deficiency and excess.Patients with Qi deficiency and blood stasis have higher serum CRP,so adequate attention should be paid to dredge Qi and blood and control inflammation in the treatment of obesity T2DM.