涤痰汤治疗急性期痰瘀阻络型缺血性卒中临床观察

Clinical Observation on Ditan Decoction in the Treatment of Acute Ischemic Stroke Patients of Phlegm and Blood Stasis Obstructing Collaterals Type

目的 探究涤痰汤加减治疗痰瘀阻络型缺血性卒中急性期患者的临床效果。方法 选取2016年6月-2019年6月在邹城市中医院内科确诊为痰瘀阻络型缺血性卒中急性期的136例患者,按抽签法随机分为对照组和观察组,各68例,对照组给予常规治疗,观察组在对照组基础上加涤痰汤加减治疗,统计临床效果。结果 观察组总有效率95.59%(65/68)高于对照组79.41%(54/68)(P<0.05)。观察组治疗后主证、次证评分,血清NF-κB、mi R-146a表达及NIHSS评分低于对照组(P<0.05)。结论 瘀阻络型缺血性卒中急性期患者经涤痰汤加减治疗,临床应用广泛。

Objective To explore the clinical effect of modified Ditan decoction on acute ischemic stroke patients with phlegm stasis obstructing collaterals type. Methods From June 2016 to June 2019,136 acute ischemic stroke patients with phlegm stasis obstructing collaterals type in Zoucheng Hospital of Traditional Chinese Medicine were randomly divided into control group and observation group according to the drawing method,with 68 cases in each group. The control group was given conventional treatment,and the observation group was treated with Ditan decoction on the basis of the control group,and the clinical effect was calculated. Results The total effective rate in observation group was 95.59%(65/68)which was higher than 79.41%(54/68)in control group(P<0.05). After treatment,the score of main syndrome and secondary syndrome,the expression of NF-κ B and mi R-146a in serum and NIHSS score in observation group were lower than those in control group(P<0.05). Conclusion Ditan decoction has been widely used in the treatment of acute ischemic stroke patients with phlegm stasis obstructing collaterals type.