淫羊藿治疗肿瘤恶病质肌肉减少症临床观察

Clinical Observation on Epimedium in the Treatment of Tumor Cachexia Myopenia

目的 探究肿瘤恶病质肌肉减少症患者行淫羊藿治疗的可行性。方法 随机将2021年1月-2021年6月厦门市中医院40例肿瘤恶病质肌肉减少症患者根据不同治疗方法分为3组。A组10例,未开展肿瘤恶病质治疗,B组10例,应用甲地孕酮治疗,C组20例,应用淫羊藿治疗。对比3组患者进食量疗效、卡氏评分疗效、体质量疗效,治疗前后瘦体组织、股四头肌群肌肉横截面积(CSA)、睾酮变化,不良反应状况。结果 经比较,B组、C组进食量、卡氏评分、体质量疗效均高于A组(P<0.05)。B组、C组瘦体组织、CSA比A组低,C组瘦体组织的改善效果比A组、B组理想(P<0.05)。A组、B组不良反应均高于C组,B组不良反应最高(P<0.05)。结论 临床治疗肿瘤恶病质肌肉减少症患者的过程中,淫羊藿的应用价值显著,且治疗安全,值得推广。

Objective To explore the feasibility of epimedium in the treatment of tumor cachexia myopenia. Methods 40 patients with tumor cachexia myopenia in Xiamen Hospital of Traditional Chinese Medicine from January 2021 to June 2021 were randomly divided into group A(n = 10,without tumor cachexia treatment),group B(n = 10,treated with megestrol)and group C(n = 20,treated with epimedium). The effects of food intake,kappa score and body mass,the changes of lean tissue,muscle cross-sectional area(CSA)of quadriceps femoris,testosterone and adverse reactions were compared before and after treatment. Results Compared with group A,group B and group C had lower food intake,Karnofsky score and body mass(P < 0.05). The lean tissue and CSA in group B and C were higher than those in group A. the improvement effect of lean tissue in group C was better than that in group A and B(P < 0.05).The adverse reactions in group A and B were higher than those in group C,and the adverse reactions in group B were the highest(P< 0.05). Conclusion In the clinical treatment of tumor cachexia myopenia,the application value of epimedium is significant,and the treatment is safe,which is worth popularizing.