黄芪当归配伍对抗肝纤维化的作用研究

Study on the Effect of Astragalus-angelica Compatibility on Anti-hepatic Fibrosis

肝纤维化(HF)是向肝硬化发展的必经阶段,严重者会转为肝癌,危害着人类健康。HF早期可以被逆转,因此,抗HF的这一逆转过程对肝硬化和肝癌的防治极为重要。黄芪当归配伍(芪归)在临床常用于活血化瘀、气血双补,对HF的逆转有较好的效果。本文分别从肝纤维化的中医理论和芪归药对配伍的相关药理学研究等方面探讨其对抗肝纤维化的作用机制,以期为临床治疗肝纤维化提供帮助。

Hepatic fibrosis(HF)is a necessary stage in the development of cirrhosis,which will seriously turn into liver cancer and endanger human health.HF can be reversed in the early stage,so this reversal process against HF is extremely important for the prevention and treatment of cirrhosis and liver cancer.Astragalus-angelica compatibility(Qigui)is commonly used in clinical practice for promoting blood circulation to remove blood stasis,qi and blood supplement,and has a good effect on the reversal of HF.In this paper,the mechanism of action against liver fibrosis was discussed from the aspects of traditional Chinese medicine theory of liver fibrosis and related pharmacological studies of Qigui drug pair compatibility,so as to provide help for clinical treatment of liver fibrosis.