奥美拉唑与兰索拉唑治疗成人活动期胃溃疡的临床疗效及对溃疡愈合的影响

Clinical Efficacy of Omeprazole and Lansoprazole in the Treatment of Active Gastric Ulcer in Adults and its Effect on Ulcer Healing

目的观察奥美拉唑与兰索拉唑治疗成人活动期胃溃疡的临床疗效。方法选取2020年5月-2021年5月在我院诊治的64例活动期胃溃疡患者为研究对象,采用随机数字表法分为对照组和观察组,各32例。对照组采用奥美拉唑治疗,观察组采用兰索拉唑治疗,比较两组治疗效果、临床症状评分、溃疡直径、愈合时间、不良反应发生情况以及溃疡愈合质量。结果观察组治疗总有效率为93.75%,与对照组的90.63%比较,差异无统计学意义(P>0.05);两组腹痛、腹胀、反酸、灼烧感评分比较,差异无统计学意义(P>0.05);观察组溃疡直径、溃疡愈合时间均小于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);观察组腺体密度和腺管形态好转率均高于对照组,差异有统计学意义(P<0.05)。结论奥美拉唑与兰索拉唑治疗成人活动期胃溃疡均可获得良好的疗效,两者在临床症状评分、不良反应方面基本一致,但兰索拉唑治疗溃疡愈合方面效果更好,具有一定的应用优势。

Objective To observe the clinical efficacy of omeprazole and lansoprazole in the treatment of active gastric ulcer in adults.Methods A total of 64 patients with active gastric ulcer who were treated in our hospital from May 2020 to May 2021 were selected as the research objects.They were divided into control group and observation group by random number table method,with 32 cases in each group.The control group was treated with omeprazole,and the observation group was treated with lansoprazole.The therapeutic effect,clinical symptom score,ulcer diameter,healing time,incidence of adverse reactions and ulcer healing quality were compared between the two groups.Results The total effective rate of the observation group was 93.75%,which was compared with 90.63%of the control group,the difference was not statistically significant(P>0.05).There was no significant difference in the scores of abdominal pain,abdominal distension,antiacidity and burning sensation between the two groups(P>0.05).The ulcer diameter and ulcer healing time in the observation group were less than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The improvement rate of gland density and gland tube morphology in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).Conclusion Omeprazole and lansoprazole have good efficacy in the treatment of active gastric ulcer in adults,both of them have no obvious advantages and disadvantages in clinical symptom score and adverse reactions,but lansoprazole has better effect in the treatment of ulcer healing and has certain application advantages.