参苓白术散加减治疗脾虚湿蕴型溃疡性结肠炎的疗效及对血清IL-10、PLT、Fib水平的影响

Efficacy of Shenlingbaizhu Powder in Treating Ulcerative Colitis with Spleen Deficiency and Damp Deposition Type and its Effect on Serum IL-10,PLT and Fib Levels

目的探讨参苓白术散加减治疗脾虚湿蕴型溃疡性结肠炎的疗效及对血清IL-10、PLT、Fib水平的影响。方法选择2020年2月-2021年2月就诊于安徽中医药大学第一附属医院肛肠科的72例UC患者作为研究对象,按照随机数字表法分为观察组和对照组,每组36例。对照组给予美沙拉嗪肠溶片治疗,观察组在对照组基础上联合参苓白术散加减治疗,比较两组临床疗效、治疗前后中医症候得分、改良Mayo评分、IL-10、PLT、Fib水平。结果观察组治疗总有效率为86.11%,高于对照组的69.44%(P<0.05);观察组治疗后中医症候得分、改良Mayo评分及IL-10、PLT、Fib水平低于对照组(P<0.05)。结论参苓白术散加减治疗脾虚湿蕴型溃疡性结肠炎效果确切,可降低患者血清炎性因子IL-10、PLT、Fib,改善患者临床症状,具有应用有效性。

Objective To explore the curative effect of Shenlingbaizhu powder in treating ulcerative colitis with spleen deficiency and damp deposition type and its effects on serum IL-10,PLT,and Fib levels.Methods A total of 72 patients with UC who were admitted to the Anorectal Department of the First Affiliated Hospital of Anhui University of Chinese Medicine from February 2020 to February 2021 were selected as the research objects.According to the random number table method,they were divided into observation group and control group,with 36 cases in each group.The control group was treated with mesalazine enteric-coated tablets,and the observation group was treated with modified Shenlingbaizhu powder on the basis of the control group.The clinical curative effect,TCM syndrome score before and after treatment,modified Mayo score,IL-10,PLT,Fib levels were compared between the two groups.Results The effective rate of treatment in the observation group was 86.11%,which was higher than 69.44%in the control group(P<0.05);after treatment,the TCM symptom score,modified Mayo score,IL-10,PLT and Fib levels in the observation group were lower than those in the control group(P<0.05).Conclusion Shenlingbaizhu powder is effective in the treatment of ulcerative colitis with spleen deficiency and damp deposition type,which can reduce the serum inflammatory factors IL-10,PLT and Fib,improve the clinical symptoms of patients,and has application effectiveness.