负荷剂量替格瑞洛在急性心肌梗死患者PCI围手术期的应用

Application of Loading Dose of Ticagrelor in Perioperative Period of PCI in Patients with Acute Myocardial Infarction

目的探讨负荷剂量替格瑞洛在急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)围手术期的应用效果。方法85例接受PCI治疗的AMI患者依据治疗方案的不同分为两组,在阿司匹林治疗基础上,观察组予以负荷剂量替格瑞洛治疗,对照组予以常规剂量替格瑞洛治疗。比较两组手术前后的血清炎性因子[降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素-6(IL-6)]以及心肌酶谱[乳酸脱氢酶(LDH)、心肌肌钙蛋白T(cTNT)、肌酸激酶同工酶(CK-MB)]。结果术后1周,观察组的血清PCT、CRP、IL-6、LDH、cTNT、CK-MB水平均显著低于对照组(P<0.05)。结论负荷剂量替格瑞洛应用于AMI患者PCI围手术期效果显著,可有效减轻患者的心肌损伤与炎性反应。

Objective To explore the application effect of loading dose of ticagrelor in perioperative period of percutaneous coronary intervention(PCI)in patients with acute myocardial infarction(AMI).Methods 85 patients with AMI who received PCI treatment were divided into two groups according to different treatment regimens.On the basis of aspirin treatment,the observation group was treated with loading dose of ticagrelor,and the control group was treated with conventional dose of ticagrelor.The serum inflammatory factors[procalcitonin(PCT),C-reactive protein(CRP),interleukin-6(IL-6)]and myocardial enzymes[lactate dehydrogenase(LDH),cardiac troponin T(cTNT),creatine kinase isoenzyme(CK-MB)]before and after surgery were compared between the two groups.Results One week after surgery,the levels of serum PCT,CRP,IL-6,LDH,cTNT and CK-MB in the observation group were significantly lower than those in the control group(P<0.05).Conclusions Loading dose of ticagrelor applied in perioperative period of PCI in patients with AMI has significant effect,and can effectively relieve myocardial injury and inflammatory reaction of patients.