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氧载体纳米药物递送系统增强光动力疗效的研究进展 被引量:1

Progress Made in Enhancing Curative Effect of Photodynamic Therapy Oxygen Carrier Nanodrug Delivery System
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摘要 缺氧(hypoxia)为大多数实体恶性肿瘤的基本特征之一,可以诱导肿瘤的恶性程度上升以及产生对多种治疗药物的耐药。目前在临床中广泛使用的耗氧型光动力疗法(photodynamic therapy,PDT)受到肿瘤局部缺氧的制约,导致PDT不能完全消灭深处缺氧区域的肿瘤细胞,在治疗后仍存在肿瘤“死灰复燃”的风险。此外,PDT是一个消耗氧气的过程,可进一步加重缺氧程度。因此,开发有效的改善肿瘤缺氧的策略和提高PDT的效率一直是PDT治疗恶性肿瘤的相关研究中所面临的一个难题。纳米微粒(nanoparticle,NP)具有很强的包容能力和载药能力,可以在搭载光敏剂(photosensitizer,PS)的同时携带其他药物,能高效地对肿瘤组织进行药物递送,协助改善缺氧及进行高效的肿瘤PDT治疗。本文论述了肿瘤缺氧与PDT的关系及其机制,并且重点介绍了氧载体纳米药物递送系统在改善肿瘤缺氧以及增强PDT疗效方面的最新研究进展与发展趋势,以期为PDT治疗肿瘤开拓新的思路。 Hypoxia is one of the basic features of most solid malignant tumors and will induce an increase in tumor malignancy and resistance to multiple therapeutic modalities.Photodynamic therapy(PDT),which is now widely used in clinical practice,is limited by local hypoxia caused by tumor.As a result,PDT cannot completely destroy the tumor cells in deep hypoxic area,which leads to a risk of tumor"resurgence"after the treatment.In addition,PDT is an oxygen-consuming process,which will further aggravate the degree of hypoxia.Therefore,the development of effective strategies to correct tumor hypoxia and increase the efficiency of PDT has been a challenge in the research area related to the PDT for cancers.Nanoparticles(NPs)are highly tolerant drug-carrying agents that may carry other drugs along with photosensitizers(PS).As a result,they will efficiently deliver drugs to tumor tissues and contribute greatly to an improvement of tumor hypoxia and enhancement of PDT efficacy.In this paper,the relationship between tumor hypoxia and PDT and the mechanisms concerned were discussed,and the latest progress and trends of the research on utilizing oxygen carrier nanodrug delivery systems to improve hypoxia and enhance PDT efficiency was highlighted.
作者 武家声 胡韶山 WU Jiasheng;HU Shaoshan(Department of Neurosurgery the Second,Affiliated Hospital of Harbin Medical University,Harbin 150086,China)
出处 《中国激光医学杂志》 CAS 2022年第1期42-50,共9页 Chinese Journal of Laser Medicine & Surgery
基金 国家自然科学基金(61575058)。
关键词 光动力治疗 恶性肿瘤 氧载体纳米药物递送系统 缺氧调节 Photodynamic therapy Malignant tumor Oxygen carrier nanodrug delivery system Hypoxia adjustment
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