静电喷雾法制备乙基纤维素/阿奇霉素复合物

Preparation of Ethyl Cellulose/Azithromycin Complex by Electrostatic Spray Method

文章以乙基纤维素(EC)为载体、阿奇霉素(AZI)为负载药物,用静电喷雾法制备不同质量比(4∶1,2∶1,1∶1,1∶2,1∶4和1∶9)EC载AZI复合物,用扫描电镜(SEM)分析复合物形貌,研究了注射速度对复合微球形貌的影响,用X射线衍射仪(XRD)和热重分析仪(TG)分析了复合物结构与热稳定性。结果表明,EC和AZI质量比2∶1时,可制备出分散性较好、粒度分布较均匀、平均粒径为5μm的圆饼状复合物,增加AZI含量导致复合物形貌不规则,增加或降低注射速度均会加剧复合物形貌不规则程度。XRD结果说明不同比例EC/AZI复合物均为无定型结构,TG结果表明不同比例EC/AZI混合物热稳定性均高于AZI,且EC和AZI质量比2∶1时,热稳定性最佳。

Using ethyl cellulose(EC) as the carrier and azithromycin(AZI) as the loaded drug, different mass ratios of EC/AZI composites(4∶1, 2∶1, 1∶1, 1∶2, 1∶4 and 1∶9) were prepared. The morphology of the composite was analyzed by scanning electron microscope(SEM), and the effect of injection speed on the morphology of composite microspheres was studied. X-ray diffractometer(XRD) and thermogravimetric analyzer(TG) were used. The structure and thermal stability of the composite were analyzed. The results showed that when the mass ratio of EC and AZI was 2∶1, a disc-like composite with better dispersion, more uniform particle size distribution, and an average particle size of 5μm could be prepared. Increasing the AZI content resulted in irregular morphology. Shape, increasing or decreasing the injection speed would aggravate the irregularity of the composite morphology. XRD results showed that EC/AZI complexes with different ratios were amorphous structures. TG results showed that the thermal stability of EC/AZI mixtures with different ratios was higher than that of AZI, and when the mass ratio of EC and AZI was 2∶1, the thermal stability was the best.