急性前葡萄膜炎患者血清TL1A的变化及意义探究

The Expression and Significance of Serum TL1A in Patients with Acute Anterior Uveitis

目的探究血清TL1A在急性前葡萄膜炎(AAU)患者中的变化及临床价值。方法选取急性前葡萄膜炎患者31例和30例匹配的健康体检者作为研究对象。酶联免疫吸附试验测定血清肿瘤坏死因子配体相关分子1A和白细胞介素17的浓度。结果AAU患者血清TL1A和IL-17浓度显著升高(p<0.05),且HLA-B27+AAU患者相较HLA-B27-的患者具有更高水平的血清TL1A和IL-17(p<0.05)。Spearman相关性分析结果显示AAU患者中血清TL1A与IL-17浓度呈显著正相关性(R=0.4307,p=0.0156)。治疗后AAU患者血清TL1A与IL-17浓度较治疗前均显著下降(p<0.05)。结论血清TL1A在AAU患者异常升高,且与患者促炎细胞因子IL-17呈显著正相关性,提示其可能参与了AAU患者的炎症免疫过程。

Objective The aim of this research was to investigate the expression and significance of serum TL1A in patients with acute anterior uveitis.Method 31 patients with acute anterior uveitis(AAU) and 30 matched healthy subjects were selected in this study. Serum concentrations of tumor necrosis factor-like cytokine 1 A(TL1A) and interleukin 17(IL-17) were measured by enzyme-linked immunosorbent assay.Result Serum concentrations of TL1A and IL-17 were significantly higher in AAU patients(p<0.05) when compared with healthy subjects. Moreover, HLA-B27+AAU patients had higher levels of serum TL1A and IL-17 compared with HLA-B27-AAU patients(p<0.05). Spearman correlation analysis result showed a significant positive correlation between TL1A and IL-17(R=0.4307,p=0.0156). Both serum TL1A and IL-17 concentrations in AAU patients decreased significantly after treatment compared with those before treatment(p<0.05). Conclusion Serum TL1A was abnormally elevated in patients with AAU and showed a significant positive correlation with pro-inflammatory cytokine IL-17, suggesting its possible involvement in the inflammatory immune process in patients with AAU.