鼻内镜辅助联合经口入路切除侵犯鼻腔鼻窦的上腭恶性肿瘤

Nasal endoscopy assisting combined with transoral approach for resection of carcinoma of the palate invading nasal cavity and sinuses

目的:探讨鼻内镜辅助联合经口入路切除侵犯鼻腔鼻窦的上腭恶性肿瘤的应用价值。方法:回顾性分析21例原发于硬腭及上颌牙槽的上腭恶性肿瘤患者病历资料,术前鼻内镜、CT和MRI检查,所有患者原发灶肿瘤均不同程度侵犯鼻腔鼻窦或颅底区域,均采用鼻内镜辅助联合经口入路切除原发灶,术后根据病理类型和临床分期辅以放疗或同步放化疗,随访并统计分析术后并发症、肿瘤全切率、肿瘤局部控制率和5年生存率。结果:所有患者均成功经此联合入路实施肿瘤切除,18例获得肿瘤整块切除,切缘阴性。中位随访期60个月,所有患者术后鼻腔通气功能良好,无溢泪,总体原发灶局部控制率85.7%,总体5年生存率76.2%。结论:鼻内镜辅助联合经口入路是切除侵犯鼻腔鼻窦的上腭恶性肿瘤的一种有效方法,有利于肿瘤整块切除,控制原发灶;有利于鼻腔鼻窦功能保留,符合功能性外科原则。

Objective:To explore the value of nasal endoscopy assisting combined with transoral approach in resection of the carcinoma of the palate with the nasal cavity and sinuses invaded.Methods:A retrospective analysis of 21 patients with a primary malignant tumors of the palate was performed.Preoperative nasal endoscopy and CT and MRI scan showed that the primary tumors invading the nasal cavity and sinuses in all patients or skull base with varying degrees.All patients were treated by nasal endoscopic assisting combined with transoral approach.Postoprational adjuvant radiotherapy or concurrent chemoradiotherapy was performed according to pathological types and clinical stage.Postoperative complications,all-tumor resection rate,local control rate and 5-year survival rate were analyzed statistically.Results:The combined approach was successfully performed in all patients.En bloc resection was carried out in 18 patients by this combined approach and surgical margins were free of carcinoma.The median follow-up period was 60 months.All patients had good nasal ventilation function and no epiphora in postoperation,and the overall local control rate of primary site was 85.7%,overall 5-year survival rate was 76.2%.Conclusion:Nasal endoscopy assisting combined with transoral approach is an effective method for the resection of palate malignant tumors invading the nasal cavity and sinuses.It is convenient for en bloc resection and local control of primary lesions.It is beneficial to preserve the function of nasal cavity and sinuses,which is in line with the principle of functional surgery.