代谢组学在中药炮制领域中的应用概述

Metabonomics and its application in Chinese medicine processing

中药炮制是指药材在中医药理论的指导下,运用我国特有的方法进行加工的过程,药材只有经适当炮制后方可入药。随着中医药现代化的发展,传统的中药炮制领域将如何继承、发扬,并走向世界,成为了一大难题。代谢组学技术是由20世纪末发展起来的一项新兴组学技术,其利用核磁共振、液质联用等方法,通过研究机体受外界刺激后内源性小分子物质代谢网络的变化,来推断机体的生理或病理状态。由于其具有整体性、全面性、动态性的特点,与中医药的整体观念不谋而合,因此近年来已经在中药炮制领域广泛应用。该文综述了代谢组学技术在中药炮制机制及炮制质量控制方面的应用,并对该技术在传统中药炮制领域的发展前景进行展望。

Chinese medicine processing is a procedure to process medicinal materials under the guidance of traditional Chinese medicine(TCM) theories by using unique methods in China.The medicinal materials can only be used clinically after proper processing.With the development of the modernization of TCM,it is difficult to solve the problems in the inheritance,development,and internationalization of Chinese medicine processing.Metabonomics,a new omics technology developed at the end of the last century,is used to infer the physiological or pathological conditions of the organism with the methods such as NMR and LC-MS via investigating the changes in endogenous small molecule metabolic network after the organism is stimulated by external environment.Metabonomics coincides with the holistic view of TCM because it displays the characteristics of integrity,comprehensiveness,and dynamics,and it has been widely applied in the field of Chinese medicine processing in recent years.This study summarized the application of metabonomics in the processing mechanism and quality control of Chinese medicine processing and prospected the development of this technology in the field of Chinese medicine processing.