2020年中国九地区120家医院住院患者血液制品使用情况调查分析

Analysis and investigation on the use of blood products among inpatients in 120 hospitals over 9 regions of China in 2020

目的调查住院患者血液制品使用情况,为后续开展其合理性评价提供参考,促进临床合理用药。方法随机抽取中国九地区120家医院2020年1月1日至2020年12月31日期间使用13种血液制品的住院患者临床数据,对血液制品处方量、使用数量、药品总费用、科室分布等进行分析。结果本研究共抽取相关处方224357张,白蛋白类、免疫球蛋白类、凝血因子类分别占比80.86%、6.87%和12.28%。九地区合计,人血白蛋白处方量、使用数量及药品总费用均位列首位,其次为人免疫球蛋白。在凝血因子类血液制品中,凝血酶处方量占比最高,其次是人纤维蛋白原、人凝血酶原复合物;重组人凝血因子类使用较少;人纤维蛋白原总费用最多。血液制品使用以重症医学科、外科系统为主,内科系统主要集中在血液内科和消化内科等少数科室。结论人血白蛋白处方量、使用数量及药品总费用占据血液制品首位,其次为人免疫球蛋白。凝血因子类制品中,凝血酶、人纤维蛋白原、人凝血酶原复合物使用较多,重组凝血因子类使用较少。

Objective To investigate the use of blood products in inpatients,to provide reference for the follow-up rationality evaluation,to promote rational clinical drug use.Methods Data of 13 kinds of blood products used by inpatients in 120hospitals over 9 regions of China from January 1,2020 to December 31,2020 were randomly selected to analyze the prescription volume,drug usage,drug expenditures,and department distribution.Results A total of 224357 prescriptions were randomly selected in the study,and the proportions of albumin,immunoglobulins and clotting factors were 80.86%,6.87%and12.28%,respectively.In total of 9 regions,the prescription volume,drug usage and drug expenditures of human serum albumin,all ranked the first,followed by human immunoglobulin.Among the blood products of coagulation factors,thrombin accounted for the highest prescription proportion,followed by human fibrinogen and human prothrombin complex.The drug expenditures of human fibrinogen accounted for the highest.Recombinant human coagulation factors were rarely used.Blood products were mainly used in intensive care unit and surgical departments,while a few departments of internal medicine,such as department of hematology and gastroenterology.Conclusion In total of 9 regions,the prescription volume,drug usage and drug expenditures of human serum albumin occupied the first place in blood products,followed by human immunoglobulin.Among coagulation factor products,thrombin,human fibrinogen,and human prothrombin complex were widely used,while recombinant coagulation factors were rarely used.