内源性刺激响应策略在肿瘤精准诊疗中的应用

Progress on Application of Endogenous Stimuli Responsive Strategies in Tumor Precision Theranostics

肿瘤微环境具有低pH值、乏氧、高谷胱甘肽含量、过表达酶以及氧化应激增加等系列异常特征。这些内源性差异在肿瘤增殖、侵袭、迁移以及新生血管生成等环节发挥重要作用,同时也为肿瘤精准诊疗提供了机遇。开发内源性刺激响应型诊疗剂已成为肿瘤精准诊疗领域的研究热点。该文综述了近年来发展的各类内源性刺激响应型诊疗体系的设计原理及其在肿瘤精准诊疗中的应用,并展望了该领域面临的问题及发展趋势,旨在为新型智能诊疗体系的构建提供理论依据和参考。

The microenvironment of tumor has a series of abnormal features,including low pH values,hypoxia,excess glutathione,increased oxidative stress and overexpressed enzymes.These endogenous factors play an important role in tumor proliferation,invasion,migration and neoangiogenesis,but they also provide opportunities for tumor precision diagnosis and treatment.The development of endogenous stimuli responsive platforms has become a research hotspot.Therefore,the design principles and the recent progress of various kinds of endogenous stimuli responsive diagnosis and treatment agents developed in recent years are summarized in this paper.The challenges and perspectives of the stimuli responsive platforms are discussed with a view to providing a theoretical basis for the construction of intelligent theranostics system.