肿瘤相关成纤维细胞对于免疫细胞的调节作用研究现状

Research Status of Tumor-associated Fibroblasts Regulating Immune Cells

肿瘤相关成纤维细胞(cancer-associated fibroblasts,CAFs)和肿瘤浸润性免疫细胞是肿瘤微环境(tumor microenvironment,TME)中重要的组成成分。二者在肿瘤微环境中相互通信,在肿瘤的发生和发展中发挥着重要作用。CAFs具有很大的异质性,不同的CAFs亚群存在着不同的功能。同时其又可以通过分泌多种细胞因子、趋化因子等方式实现对肿瘤浸润性免疫细胞的调节,从而进一步影响肿瘤的发生、发展、侵袭、转移等生物学行为。本文对国内外近年来有关CAFs在TME中对浸润性免疫细胞调节作用的研究现状作一综述。

Cancer-associated fibroblasts(CAFs) and tumor-infiltrating immune cells are the most essential components of the tumor microenvironment(TME).They communicate with each other in tumor microenvironment and play a critical role in tumorigenesis and development.CAFs are very heterogeneous and different subtypes of CAFs display different functions.At the same time,it can contribute to the regulation of the function of tumor-infiltrating immune cells and eventually result in the carcinogenesis,tumor progression,invasion,metastasis and other biological behaviors of tumors by producting various growth factors and cytokines etc.Based on the current research results at home and abroad,this paper reviews the recent research progress on the regulation of CAFs on infiltrating immune cells in tumor micro environment.