摘要
In this paper,a new organic–inorganic hybrid compound[Co(L)_(2)]2[W_(6)O_(19)](1)(HL=2-acetylpyridine thiosemicarbazone)was prepared and characterized.The compound 1 exhibits remarkable antibacterial activity by determination of minimum inhibitory concentration(MIC)against Staphylococcus aureus(S.aureus,0.06μg·mL^(−1))and Escherichia coli(E.coli,0.24μg·mL^(−1)),respectively.Furthermore,the potential mechanism of compound 1 was studied in detail.The potential causes of bacteria death were cell wall/membrane disruption,inhibition of intracellular respiratory chain dehydrogenases(RCD)activity,destruction of reactive oxygen species(ROS)and depletion of glutathione(GSH).
基金
financially supported by the National Natural Science Foundation of China (Grant No.21671055)
Henan University First-class Discipline Cultivation Project (Grant No.2020YLZDYJ06)
Medical Interdisciplinary Training Program of Henan University of China (Grant No.CJ1205A0240007)
the Scientific and Technological Project of Henan province (Grant No. 212102310852)
