体部立体定向放射治疗联合免疫检查点抑制剂在非小细胞肺癌中的应用

Application of the combination of stereotactic body radiation therapy and immune checkpoint inhibitors in non-small cell lung cancer

针对非小细胞肺癌(NSCLC),目前的主要治疗手段是手术、化疗、放疗、靶向治疗、免疫治疗等多种疗法的结合。立体定向放射治疗(SBRT)的应用越来越广泛,基于SBRT的免疫调节效应,SBRT联合免疫检查点抑制剂(ICI)可应用于各期别NSCLC。SBRT联合ICI治疗模式需不断探索以发挥最佳的放射免疫协同作用。

The major treatments of non-small cell cancer(NSCLC)contain surgery,chemotherapy,radiotherapy,targeted therapy,immunotherapy and the combinations of them.Among them,stereotactic body radiation therapy(SBRT)is applied more and more extensively.Based on the immunoregulatory effects of SBRT,the combination with immune checkpoint inhibitors(ICIs)is used in all stages of NSCLC.This kind of treatment mode needs to be continuously explored to maximize the radio-immunity synergistic effect.