药物性痤疮的研究进展

The Research Progress of Drug-induced Acne

药物性痤疮为服用药物后出现或加重的痤疮样皮疹,通常具以下特征:即单形性模式、不局限于皮脂溢出部位、不寻常的发病年龄、对传统痤疮治疗的抵抗。引起痤疮样皮疹的药物种类较多,包括糖皮质激素、神经精神类药物、抗结核药物和免疫调节类药物等。最近,肿瘤治疗领域的靶向药物,如表皮生长因子受体抑制剂等引起的痤疮样皮疹的发生率有所升高。本文旨在对药物性皮炎的临床表现、发病原因及治疗进展进行综述,以期为临床提供参考。

Drug-induced acne is an acne-like eruption caused or aggravated by certain medication.Drug-induced acne is characterized by a monomorphic pattern,an unusual location of the lesions beyond the seborrheic areas,an unusual age of onset,a resistance to conventional acne therapy.Many drugs can be responsible for such symptoms such as corticosteroids,neuropsychotherapeutic drugs,antituberculosis drugs,and immunomodulating molecules.Recently,targeted therapy in the field of oncology,such as epidermal growth factor receptor inhibitors,have been associated with an increased frequency of this adverse effect.This article reviews the advances in the study of the clinical manifestations,causes and drug therapies of drug-induced acne to provide reference for clinical practitioners.