基于核磁共振波谱的代谢组学分析在肿瘤诊疗中的应用进展

Application progress of metabolomic analysis based on nuclear magnetic resonance spectroscopy in tumor diagnosis and treatment

核磁共振波谱是代谢组学的主要分析技术之一,该技术具有操作简单、快速和非侵入性等优点,通过监测机体代谢物的变化,有助于深入了解疾病机制,能够在疾病诊疗中发挥作用,但其临床应用尚未普及。近年来,代谢组学在肿瘤中的应用日益成为研究热点,因此本文围绕核磁共振波谱技术和肿瘤代谢组学,着重介绍基于该技术的代谢组学分析在肿瘤早期筛查、临床诊断和预后评估等方面的应用进展,以期为肿瘤代谢组学的研究和临床应用提供参考。

Nuclear magnetic resonance spectroscopy is one of the main analytical techniques for detecting metabolomics,which has the advantages of simple operation,rapid detection and non-invasive feature.By monitoring the changes of metabolites in the body,it is helpful to deeply understand the mechanism of disease and play a role in the diagnosis and treatment of diseases,but its clinical application has not yet been popularized.In recent years,the application of metabolomics in tumors has increasingly become a research hotspot.Therefore,in order to provide a reference for the research and clinical application of tumor metabolomics,the nuclear magnetic resonance spectroscopy and tumor metabolomics were introduced in this paper,and the application progress of metabolomics analysis based on this technique in early tumor screening,clinical diagnosis and prognosis evaluation were reviewed in this paper.